In Silico Elucidating the Common Gene-Regulatory-Network(S) Of Accelerated Cell Death (Acd11) from Arabidopsis Thaliana and Its Orthologs

Abstract

The Arabidopsis accelerated cell death 11 (acd11) is a genetic model for studying immune response activation and localized cellular suicide that prevent pathogen spread during plant infection. In this research article we predicted the common gene-regulatory-network of accelerated cell death (acd11) from Arabidopsis thaliana and its orthologs with the help of well-known bioinformatics tools.  The most common orthologs were extracted from Phytzome and PLAZA on the basis of protein sequence similarity using BLASTp. Developmental expression analysis from Genevestigator concluded the acd11 is highly expressed at last developmental stage and co-expressed with Autophagy related and Disease resistant genes. PPI from STRING network confirm that its interacting partners are EDS1 and LAZ1 both of which play an important role in disease resistant and programmed cell death respectively. Protein disorder from DisEMBL confirm its diverse functioning properties and non-stable structure. Ligand binding study from RaptorX predicted that residues in the Active site pocket Asparagine and Histidine.